IN TWO MOUSE MODELS OF ALZHEIMERíS DISEASE COPPER DIDNíT INCREASE TOXICITY

 

 

In two mouse models of Alzheimerís disease, in contrast with previous in vitro results, researchers found that copper could contrast beta-amyloid toxicity.

In the first paper Bayer et al. (Dietary Cu stabilizes brain superoxide dismutase1 activity and reduces amyloid Aβ production in APP23 transgenic mice, Proc. Natl Acad. Sci. USA 100, 14187-14192, 2003) demonstrated that in APP23 transgenic mice dietary copper restores the activity of superoxide dismutase 1 (SOD1), which was reduced by the overexpression of the amyloid precursor protein (APP), and also lower levels of β-amyloid in the brain.

In the second mouse model Phinney et al. (In vivo reduction of amyloid-β by a mutant copper transporter, Proc. Natl Acad. Sci. USA 100, 14193-14198, 2003) found that in the homozygous variant for a mutant copper transporter that causes accumulation of copper in the cytoplasm, levels of β-amyloid and deposition of amyloid plaques are reduced.††

 

BM&L-January 2004