Targeting apoptosis in neurodegenerative disease



An accurate work of review by Miquel Vila and Serge Przedborski (Targeting programmed cell death in neurodegenerative disease, Nature Review Neuroscience, Vol. 4, No 5, May 2003) will be published in the May issue of Nature Review Neuroscience.

Molecular pathways of apoptosis are activated in various neurodegenerative disorders including Amyotrophic Lateral Sclerosis (so called Lou Gehrig disease), Parkinson's disease, Alzheimer’s and Huntington's. In these diseases, apoptosis (or programmed cell death, PCD) might be pathogenic, and targeting it might mitigate degeneration. To identify potential neuroprotective targets within the PCD process complex, the expression and activity of some of its components have been altered by genetic or pharmacological means in experimental models of neurodegenerative diseases. The results of these studies have provided leads for the development of neuro-protective strategies for these progressive, disabling and often fatal disorders.

                                                                                                                     BM&L-April 2003