Silent Brain Infarcts in 1015 people and the Risk of Dementia and
Cognitive Decline
1015 people 60 to 90 of age was studied by cerebral
mri and neuropsychological testing with interesting results
In
USA and many other countries, neurologists often neglect the importance as well
as the monitoring of silent brain infarcts. Sarah Vermeer’s study gives them
and us a proportion of the problem. Silent
brain infarcts are frequently seen on magnetic resonance imaging
(MRI) in healthy elderly people and sometimes incidentally revealed by CT-scan
executed for other purposes, yet the real incidence of cognitive impairment or
decline related to the pathology is still largely unknown. The prospective
population-based Rotterdam Scan Study, including 1015 people 60 to 90 years of
age and free of dementia and stroke at baseline (Sarah E. Vermeer et al., Silent Brain Infarcts and the Risk of Dementia and Cognitive
Decline, New England Journal of Medicine, March 27 issue, Number 13,
Vol. 348, 1215-1222, 2003) found a more than
doubled risk of dementia (hazard ratio, 2.26; 95 percent confidence
interval, 1.09 to 4.70) in people with silent brain infarct at the baseline
MRI.
Participants
underwent neuropsychological testing and cerebral MRI at base line
in 1995 to 1996 and again in 1999 to 2000 and were monitored for
dementia throughout the study period. The authors performed Cox
proportional-hazards and multiple linear-regression analyses,
adjusted for age, sex, and level of education and for the presence
of white matter lesions and the presence-absence of subcortical atrophy. During
3697 person-years of follow-up (mean per person, 3.6 years) dementia
developed in 30 of the 1015 participants.
The
presence of silent brain infarcts on the base-line MRI was
associated with worse performance on neuropsychological tests and a
steeper decline in global cognitive function. Silent thalamic
infarcts were associated with a decline in memory performance, and
non-thalamic infarcts with a decline in psychomotor speed. When
participants with silent brain infarcts at base line were subdivided
into those with and those without additional infarcts at follow-up,
the decline in cognitive function was restricted to those with additional
silent infarcts.
Sarah
Vermeer and her colleagues concluded that silent brain infarct represents a
defined increased risk of dementia and accelerates cognitive decline in elderly
people.
BM&L-March
2003
Source
Information.
From the Departments of Epidemiology and
Biostatistics (S.E.V., N.D.P., T.H., A.H., M.M.B.B.), and Neurology (S.E.V.,
N.D.P., T.H., P.J.K.), Erasmus Medical Center, Rotterdam, the Netherlands.
Address reprint requests to Dr. Breteler at the Department of Epidemiology and
Biostatistics, Erasmus Medical Center, P.O. Box 1738, 3000 DR Rotterdam, the
Netherlands, or at m.breteler@erasmusmc.nl.