PRINCIPLES OF NEURAL SCIENCES
Fifth Edition, 2013.
From the publisher’s note.
Now updated: the definitive neuroscience resource from
Eric R. Kandel, MD (winner of the Nobel Prize in 2000); James H. Schwartz, MD,
PhD; Thomas M. Jessell, PhD; Steven A. Siegelbaum, PhD; and A. J. Hudspeth, PhD.
McGraw Hill Medical - 900
full-color illustrations – Art Editor Sarah Mack.
Deciphering the link between the human brain and behavior has always been one
of the most intriguing and often challenging aspects of scientific endeavor.
The sequencing of the human genome, and advances in molecular biology, have
illuminated the pathogenesis of many neurological diseases and have propelled
our knowledge of how the brain controls behavior.
To grasp the wider implications of these developments and gain a fundamental
understanding of this dynamic, fast-moving field, Principles of Neuroscience
stands alone as the most authoritative and indispensible resource of its kind.
In this classic text, prominent researchers in the field expertly survey the
entire spectrum of neural science, giving an up-to-date, unparalleled view of
the discipline for anyone who studies brain and mind. Here, in one remarkable
volume, is the current state of neural science knowledge ranging from molecules
and cells, to anatomic structures and systems, to the senses and cognitive
functions all supported by more than 900 precise, full-color illustrations. In
addition to clarifying complex topics, the book also benefits from a cohesive
organization, beginning with an insightful overview of the interrelationships
between the brain, nervous system, genes, and behavior. Principles of Neural
Science then proceeds with an in-depth examination of the molecular and
cellular biology of nerve cells, synaptic transmission, and the neural basis of
cognition. The remaining sections illuminate how cells, molecules, and systems
give us sight, hearing, touch, movement, thought, learning, memories, and
The new fifth edition of Principles of Neural Science is thoroughly
updated to reflect the tremendous amount of research, and the very latest
clinical perspectives, that have significantly transformed the field within the
Ultimately, Principles of Neural Science affirms that all behavior is an
expression of neural activity, and that the future of clinical neurology and
psychiatry hinges on the progress of neural science. Far exceeding the scope
and scholarship of similar texts, this unmatched guide offers a commanding,
scientifically rigorous perspective on the molecular mechanisms of neural
function and disease one that you'll continually rely on to advance your
comprehension of brain, mind, and behavior.
- The cornerstone reference in the field of
neuroscience that explains how the nerves, brain, and mind function
- Clear emphasis on how behavior can be examined
through the electrical activity of both individual neurons and systems of
- Current focus on molecular biology as a tool for
probing the pathogenesis of many neurological diseases, including muscular
dystrophy, Huntington disease, and certain forms of Alzheimer's disease
- More than 900 engaging full-color illustrations including
line drawings, radiographs, micrographs, and medical photographs clarify
often-complex neuroscience concepts
- Outstanding section on the development and
emergence of behavior, including important coverage of brain damage
repair, the sexual differentiation of the nervous system, and the aging
- NEW! More detailed discussions of cognitive and
behavioral functions, and an expanded review of cognitive processes
- NEW! A focus on the increasing importance of
computational neural science, which enhances our ability to record the
brain's electrical activity and study cognitive processes more directly
- NEW! Chapter-opening Key Concepts provide a
convenient, study-enhancing introduction to the material covered in each
- Selected Readings and full reference citations at
the close of each chapter facilitate further study and research
- Helpful appendices highlight basic circuit
theory; the neurological examination of the patient; circulation of the
brain; the blood-brain barrier, choroid plexus, and cerebrospinal fluid;
neural networks; and theoretical approaches to neuroscience.
“The ultimate goal of neural science is to understand
how the flow of electrical signals through neural circuits gives rise to mind –
to how we perceive, act, think, learn and remember. Although we are still many
decades away from achieving this level of understanding, neuroscientists have
made significant progress in gaining insight into the neural mechanisms
underlying behavior, the observable output of the nervous system of humans and
other organisms. We are also beginning to understand the disorders of behavior
associated with neurological and psychiatric disease. As in the earlier
editions of this book, we emphasize in this edition that behavior can be
examined in terms of the electrical activity of both individual neurons and
systems of nerve cells by seeking answers to five basic questions. How does the
brain develop? How do nerve cells in the brain communicate with one another?
How do different patterns of interconnections give rise to different
perceptions and motor acts? How is the communication between neurons modified
by experience? How is communication altered by disease?”
book we document the central principle that all behavior is an expression of
neural activity and illustrate the insights into behavior that neural science
provides. With this fifth edition we again hope to encourage the next
generation of undergraduate, graduate, and medical students to approach the
study of behavior in a way that unites its biological and social dimensions”.
For Italian speakers we recommend on BM&L-Italy website pages “La nuova edizione dei Principles of Neural Science di Kandel, Schwartz, Jessell, Siegelbaum, Hudspeth”,
weekly published from October 27, 2012 to November 24, 2012.