PATHOLOGIC PRION PROTEIN is deposited in the neuroepithelium of the
olfactory mucosa in patients with sporadic Creutzfeldt–Jakob disease
indicating that olfactory biopsy may provide diagnostic
information in living patients
Zanusso,
G. et al. Detection of Pathologic Prion Protein in the
Olfactory Epithelium in Sporadic Creutzfeldt–Jakob Disease, New England
Journal of Medicine, Volume 348:711-719, Feb 20, 2003.
More
Information at the Departments of
Neurologic and Visual Sciences (G.Z., S.F., M. Gelati, M.F., A.F., T.C., N.R.,
S.M.), Ear, Nose, and Throat (P.Z.), Morphologic and Biomedical Sciences
(M.B.), and Agricultural and Industrial Biotechnologies (P.G.R.), Section of
Clinical Neurology, University of Verona, Verona; the Laboratory of Virology,
Istituto Superiore di Sanità, Rome (F.C., M.P.); and the Department of
Pathology, University of Padua, Padua (M. Gardiman) — all in Italy. Address
reprint requests to Dr. Monaco at the Section of Clinical Neurology, Department
of Neurologic and Visual Sciences, Policlinico G.B. Rossi, Piazzale L.A. Scuro
10, 37134 Verona, Italy, or at salvatore.monaco@mail.univr.it.
BM&L-March
2003