PATHOLOGIC PRION PROTEIN is deposited in the neuroepithelium of the olfactory mucosa in patients with sporadic Creutzfeldt–Jakob disease

indicating that olfactory biopsy may provide diagnostic information in living patients


Zanusso, G. et al. Detection of Pathologic Prion Protein in the Olfactory Epithelium in Sporadic Creutzfeldt–Jakob Disease, New England Journal of Medicine, Volume 348:711-719, Feb 20, 2003.

More Information at the Departments of Neurologic and Visual Sciences (G.Z., S.F., M. Gelati, M.F., A.F., T.C., N.R., S.M.), Ear, Nose, and Throat (P.Z.), Morphologic and Biomedical Sciences (M.B.), and Agricultural and Industrial Biotechnologies (P.G.R.), Section of Clinical Neurology, University of Verona, Verona; the Laboratory of Virology, Istituto Superiore di Sanità, Rome (F.C., M.P.); and the Department of Pathology, University of Padua, Padua (M. Gardiman) — all in Italy. Address reprint requests to Dr. Monaco at the Section of Clinical Neurology, Department of Neurologic and Visual Sciences, Policlinico G.B. Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy, or at

                                                                                                                  BM&L-March 2003