Conversion of purified oligodendrocyte precursor cells (OPCs) to neural stem cells requires chromatin remodelling and histone modification. This is what emerges from a research conducted by Kondo and Raff who analysed the molecular mechanism that underlie the conversion of OPCs to neural stem-like cells (NSLCs).

NSLCs can generate both neurons and glia, so they could provide a source of neurons for CNS repair. 

The research shows that OPCs conversion depends on the reactivation of Sox2 gene expression, which in turn depends on chromatin remodelling at the Sox2 promoter (Kondo T. & Raff M., Chromatin remodelling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells. Genes Dev. 18, 2963-2972, 2004).       


BM&L-January 2005