Application of proteomics to the study of molecular mechanisms in NEUROTOXICOLOGY


A variety of classic proteomic techniques as well as more recently developed approaches are available to determine protein levels, identify components of multiprotein complexes and to detect post-translational changes upon exposure to neurotoxicants (Neurotoxicology 24, 761-765, 2003). Proteomics can provide quantitative data regarding changes in corresponding expression levels and/or post-translational modifications that might be associated with neuron injury.

BM&L-ELSEVIER BioMedNet - March 2004