Neuregulin-1 mediates intracellular signalling
Neuregulin-1 is a protein involved in the formation process of some synapses. Its exact role is still unknown, but new insights come from research.
Neuregulin-1 receptors are transmembrane tyrosine kinases called “erb B”, which have an intracellular signaling function. It seems (Bao J. et al., Back signaling by the Nrg-1 intracellular domain, J. Cell Biol. 161, 1133-1141, 2003) that neuregulin-1 itself mediates intracellular signaling. According to results, we must add neuregulin-1 to the molecules regulated by transmembrane proteolysis.