MARIJUANA THC, AS WELL AS MUSTARD OIL, EXCITE SENSORY NERVE

Jordt and his colleagues (Mustard oils and cannabinoids excite sensory nerve fibers through the TRP channel ANKTM1. Nature 427, 260-265, 2004) show that isothiocyanate compounds and Δ9-tetrahydrocannabinol (THC) activate a transient receptor potential ion channel called ANKTM1. Through ANKTM1, isothiocyanate produce pain, inflammation, and hypersensitivity when applied to the skin.

BM&L- April 2004