INTEGRINS AND MECHANISMS OF CHRONIC PAIN

Dina et al. (O. A. Dina et al. Integrin signaling in inflammatory and neuropathic pain in the rat. European Journal of Neuroscience 19, 634-642, 2004) show evidence that specific integrin subunits are involved in pathways that cause pain when stimulated by different substances: although studies of potential treatment of inflammatory and neuropathic pain on this basis are warranted, progress in treating chronic pain will be relatively slow for the complexity of the problem itself.

BM&L- April 2004