DISCOVERED GLIOMEDIN ROLE AT THE NODES
Eshed and his colleagues discovered a protein expressed at Schwann microvilli responsible for the formation of complexes containing Na+ channels at nodes of Ranvier (Gliomedin mediates Schwann cell-axon interaction and the molecular assembly of the nodes of Ranvier. Neuron 47, 215-229, 2005).
The protein, called gliomedin, is a ligand of two CAMs, neurofascin and nrCAM, which in turn bind Na+ channels. Disrupting gliomedin localization or expression, suppressed the characteristic clustering of Na+ channels.