Candidate genes for anorexia nervosa

in the 1p33-36 linkage region:

serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa



A. W. Bergen et al. (Molecular Psychiatry, Volume 8, Number 4, 397-406, 2003) conducted a genetic study on the etiology of the Anorexia Nervosa (AN) finding a statistical link between two receptors genes and the syndrome, as it is defined by DSM-IV criteria, in 191 people. The relationship between genetic variation of receptors (5-HT receptor 1D, or HTR-1D, and opioid delta receptor or OPR-D1) and a mental disorder like Anorexia Nervosa is complex and its value opinable.

BM&L-May 2003