Gating of the gaba-a receptor channel
HOW AGONIST BINDING LEADS TO OPENING THE PORE: COMPELLING EVIDENCE
Kash T. L. et al. (Coupling of agonist binding to
channel gating in the GABA-A receptor, Nature 421, 272-275, 2003) demonstrate that for
gating of the GABA-A receptor channel are crucial electrostatic interactions
between residues of the extracellular domain
and the linker between two transmembrane domains.
Although the paper could
appear too technical to those who are not expert in protein chemistry, we
suggest of reading the full text that we found interesting and effectively
illustrated.
BM&L-March 2003