bipolar disorder: a new genetic link



Barrett and his colleagues (Evidence that a single nucleotide polymorphism in the promoter of the G-protein-receptor kinase 3 gene is associated with bipolar disorder, Mol. Psychiatry 8, 546-557, 2003) propose that alterations in expression of the gene for the G-protein-receptor kinase 3 (GRK3) might result in an increased susceptibility to bipolar (manic-depressive) disorder.

GRK3 is involved in the desensitization of G-protein-coupled receptors. Barrett and his co-workers looked for GRK3 alterations in people suffering from bipolar syndromes and found a suggestive link with a single-nucleotide polymorphism in the 5 untranslated region (the promoter) of the GRK3 gene.


BM&L-September 2003