A new therapy for Parkinson’s disease
Direct brain infusion of a protein
Steven
Gill of the Institute of Neuroscience in Bristol leads a team of researchers
who have implanted a thin plastic tube into the patients’ brain and a small
pump in their stomach, infusing a protein (GDNF) known to nourish the neurons
that degenerate in Parkinson’s disease. The protein is a trophic molecule
called glial-cell-line-derived neurotrophic factor (GDNF) which has been
administered for two years. It seems that dopaminergic cells involved in the
pathologic process of degeneration began to sprout and produced more dopamine;
it is the first time a treatment has reversed disease progression.
One
of the patient on trial, previously housebound, has joined a bowls team (S. S. Gill et al. Direct brain infusion of glial cell line
derived neurotrophic factor in Parkinson disease. Nature Medicine,
published online, doi:10.1038/nm850, 2003).
Although
Gill thinks that in five years this could become a routine treatment, we
suggest to take the results with a pinch of salt and wait for more controlled
studies outcome: a long term infusion might cause unknown effects.
BML-
April 2003