Aberrant
Ubiquitin in Alzheimer’s disease
Ubiquitine/proteasome
system may have a role in degenerative diseases such as Parkinson’s and
Alzheimer’s disease.
To investigate in vivo
this degradative machinery Dantuma’s group have developed a transgenic mouse
model that carry a green fluorescent protein (GFP) reporter with a
constitutively active degradation signal.
Lindsten et al. (A transgenic mouse
model of the ubiquitin/proteasome system. Nature Biotechnol. 20, July
2003 – doi:10.1038/nbt851) confirmed the in vivo functionality of the
reporter and found that its accumulation was induced in primary neurons by an
aberrant ubiquitin previously described in Alzheimer’s disease.